As you get started with TECENTRIQ + Avastin® (bevacizumab), note any changes in how you feel. You may feel some of the side effects below. You may also have less common side effects that aren’t listed here. Some can be serious. Others may be managed. If you have any side effects, or notice any symptoms of side effects, let your healthcare team know. You can learn more about all the potential side effects in the Medication Guide.

Here is a list of the most common side effects of TECENTRIQ + Avastin. Learn about specific tips by selecting each side effect below.


High blood pressure

Taking TECENTRIQ + Avastin may cause your blood pressure to rise. Your healthcare team will check your blood pressure each time they see you. Your doctor can help you address changes in your blood pressure.

Feeling tired or weak

Tips to try

  • Plan time to rest: Short naps may help. But don’t sleep too much during the day
  • Balance rest and activity: Short walks and light exercise may help. It’s also important to relax when possible
  • Meet with a dietitian: He or she can help you learn about foods and drinks that can boost your energy

Too much protein in the urine

Taking TECENTRIQ + Avastin may cause an increase in protein in your urine. Your healthcare team will do tests to monitor for this and make changes if necessary.

Itching or rash

Tips to try

  • Moisturize: Ask your healthcare team to recommend a cream or lotion. There may be prescription creams or medicines that could help
  • Don’t use hot water: Use slightly cooler water to protect your skin
  • Limit your time in the sun: Use sunscreen with an SPF of at least 15. Wear a wide-brimmed hat and try to avoid the midday sun

Diarrhea

Tips to try

  • Drink fluids: Diarrhea can make you dehydrated, so be sure to drink more liquids
  • Eat small meals: Break your mealtime into 6 to 8 smaller meals
  • Choose different foods: Try the “BRAT” diet. Eat Bananas, Rice, Applesauce, and Toast in small amounts

Fever

Tips to try

  • Drink plenty of fluids: When you have a fever, your body will lose fluids, so it’s important to replace them
  • Cool off: An ice pack or a cool cloth on your forehead can help you feel cooler
  • Ask before taking medicine: If you want to take a medicine for your fever, talk to your healthcare team first

Decreased appetite

Tips to try

  • Drink plenty of liquids: Make sure you are drinking enough liquids to help you stay hydrated
  • Eat healthy foods: Even if you aren't hungry, try to eat a little. Focus on eating smaller meals that are high in protein and calories
  • Stay active: Even a short walk can help increase your appetite

Constipation

Tips to try

  • Eat more fiber: Ask your healthcare team how many grams of fiber you should get. Adding bran, like you find in cereal or a smoothie, may help
  • Drink water: Most people need 8 to 12 cups of water every day
  • Stay active: A light walk may help with constipation. If that’s too much for you, talk to your healthcare team about simple exercises you can try

Pain in stomach area

Tips to try

  • Drink fluids: Drinking more fluids may help. Make sure your healthcare team says this is okay
  • Take all medicines with food: Eating food before taking your medicines can help a stomachache. Check with your doctor to make sure this is okay
  • Avoid alcohol and tobacco: Both can upset your stomach
  • See tips for diarrhea and nausea and vomiting for more ideas

Nausea and vomiting

Tips to try

  • Drink fluids: Drinking plenty of fluids is very important, especially if you have been throwing up
  • Eat bland foods: Sweet, fried, greasy, or spicy foods can all cause you to feel sick. Cut them out if they bother your stomach
  • Try cold foods: If the smells of certain foods make you feel sick, try eating them cold. This will lessen the smell
  • Talk to your healthcare team: They may prescribe an anti-nausea medicine

Cough

Tips to try

  • Breathe in some steam: Taking a hot shower can loosen up the phlegm in your nose and throat
  • Avoid smoke: Don’t smoke or be around those who smoke
  • Use cough drops: Talk to your healthcare team about which cough drops are right for you

Decreased weight

Tips to try

  • Track what you eat: Share your notes with your healthcare team. You may find that certain foods or mealtimes work better than others
  • Eat several light meals: Replace regular mealtimes with 5 or 6 smaller meals

Reactions to infusions

Tips to try

  • Ask questions about your infusions: Your healthcare team can help you learn what reactions to look for. They can also suggest ways to manage the side effects you have

Nosebleeds

Tips to try

To stop a nosebleed:

  • Stay upright or lean forward: Don’t lie down or tilt your head back
  • Pinch your nose: Apply pressure just below the bone in the bridge of your nose
  • Apply ice: Cooling your nose may help the bleeding stop

To prevent future nosebleeds:

  • Avoid putting things in your nose: This includes tissues or fingers
  • Use a humidifier: This can help keep your nose moist

Contact your healthcare team if:

  1. you can’t get a nosebleed to stop after 15-30 minutes
  2. you have frequent nosebleeds

TECENTRIQ + Avastin may cause serious side effects

TECENTRIQ can cause your immune system to attack normal organs and tissues and can affect the way they work. These problems can sometimes become serious or life threatening and can lead to death.

Possible serious side effects with TECENTRIQ include, but are not limited to, lung problems (pneumonitis), liver problems (hepatitis), intestinal problems (colitis), hormone gland problems (especially the thyroid, adrenal glands, pancreas, and pituitary), problems in other organs, severe infections, and severe infusion reactions.

You can learn more about the signs and symptoms of these and other side effects in the TECENTRIQ Medication Guide.

Work with your healthcare team to address any side effects that you may have. You can also find tips for managing side effects of cancer treatment at the National Cancer Institute website.

Please be aware that links to third-party sites are provided for convenience only. Genentech is not responsible for the accuracy of the information contained on a third-party site and does not recommend or endorse the content provided on the site.

The information provided by these organizations is meant for informational purposes only and is not meant to replace a doctor’s medical advice. Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites.

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