For US Healthcare Professionals

There are 2 ways to receive your treatment

TECENTRIQ can be taken by injection or infusion. Talk with your doctor to decide which option will work best for you.

Injection Infusion

TECENTRIQ HYBREZA injections

TECENTRIQ HYBREZA is the first PD-L1 immunotherapy available as an injection. Each TECENTRIQ HYBREZA injection lasts about 7 minutes.

TECENTRIQ HYBREZA injections are given under the skin in your thigh once every 3 weeks. Depending on your treatment plan, you may need to see your doctor between injections. For people with MIBC, treatment with TECENTRIQ HYBREZA is usually given for up to 1 year.

Learn more about TECENTRIQ HYBREZA.

PD-L1=the biomarker called programmed death-ligand 1.

Tips for treatment and staying on track

Use these tips to prepare for treatment for starting TECENTRIQ HYBREZA injections:

Make sure treatment is on your schedule

Set a reminder for your appointment on your calendar or in your phone.

Bring a companion

You may want to ask a family member or friend to come with you to keep you company.

Wear shorts, a dress, or loose pants

You may want to put on clothing that makes it easy to access your thigh, because that is where TECENTRIQ HYBREZA injections are given.

Stay warm

Some people feel cold during their injection, so you may want to bring a warm blanket.

Ask questions

Use the time that you have with your healthcare provider or nurse to ask any questions you have about treatment. You can also take notes so you can look back and remember what you heard.

Take deep breaths

If you are nervous about needles, looking away from the injection site and taking slow, deep breaths may help you feel calm during the injection.

Entertain yourself

You may also want to use this time to read a magazine or newspaper, scroll through social media, or watch a short video on your phone.

Keep track of where your injection was given

While it’s fresh in your mind, jot down which thigh you had your injection in so you can alternate the area next time.

TECENTRIQ infusions

You receive TECENTRIQ infusions into a vein through an intravenous (IV) line. If the first 60-minute infusion is well tolerated, all following TECENTRIQ infusions may be given over 30 minutes. If TECENTRIQ is one part of your treatment, infusion time may be longer.

TECENTRIQ infusions have flexible dosing options and can be given every 2, 3, or 4 weeks. Depending on your treatment plan, you may need to see your doctor more frequently. You and your doctor will decide which treatment schedule is best for you. For people with MIBC, treatment with TECENTRIQ is usually given for up to 1 year.*

Be sure to start a conversation with your doctor when deciding which option will work better for your lifestyle.

*TECENTRIQ infusions will be given as 840 mg every 2 weeks, 1200 mg every 3 weeks, or 1680 mg every 4 weeks.

Tips for treatment and staying on track

Use these tips to prepare for treatment for starting TECENTRIQ infusions:

Stay warm

Some people feel cold during their infusion, so you may want to bring a warm blanket.

Bring a companion

Ask a family member or friend to give you a ride and keep you company during your infusion.

Dress comfortably

Some appointments take longer than others, so you may want to wear comfortable clothes.

Pass the time

Entertain yourself with a book, a tablet, or your phone loaded with a TV show or podcast.

Pack a snack

Ask your care team if it's okay to bring some light snacks or a bottle of water.

Take notes

Bring a pen and your treatment journal (or a notepad) to jot down any questions or thoughts that come up.

NEXT: Questions to Ask Your Doctor

Important Safety Information and Indication

Indication

What are TECENTRIQ and TECENTRIQ HYBREZA?

TECENTRIQ (atezolizumab) and TECENTRIQ HYBREZA (atezolizumab and hyaluronidase-tqjs) are prescription medicines used to treat:

Adults with a type of bladder cancer called muscle invasive bladder cancer (MIBC) that has spread into the muscle layer of the bladder but not to other parts of the body. TECENTRIQ or TECENTRIQ HYBREZA may be used alone as a treatment for your bladder cancer:

  • to help prevent your bladder cancer from coming back after your bladder has been removed by surgery, and
  • small pieces of DNA from the tumor (called circulating tumor DNA [ctDNA]) were found in your blood, showing that cancer cells remain in the body (molecular residual disease). Your healthcare provider will perform a test to make sure that TECENTRIQ or TECENTRIQ HYBREZA is right for you.

It is not known if TECENTRIQ HYBREZA is safe and effective when used:

  • in children for the treatment of MIBC.

It is not known if TECENTRIQ is safe and effective when used:

  • in children for the treatment of MIBC.

Important Safety Information

Who should not receive TECENTRIQ HYBREZA?                                     

Do not receive TECENTRIQ HYBREZA if you are allergic to hyaluronidase or any of the ingredients in TECENTRIQ HYBREZA

What is the most important information about TECENTRIQ and TECENTRIQ HYBREZA?

TECENTRIQ and TECENTRIQ HYBREZA can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

Lung problems

  • cough
  • shortness of breath
  • chest pain

Intestinal problems

  • diarrhea (loose stools) or more frequent bowel movements than usual
  • stools that are black, tarry, sticky, or have blood or mucus
  • severe stomach-area (abdomen) pain or tenderness

Liver problems

  • yellowing of your skin or the whites of your eyes
  • severe nausea or vomiting
  • pain on the right side of your stomach area (abdomen)
  • dark urine (tea colored)
  • bleeding or bruising more easily than normal

Hormone gland problems

  • headaches that will not go away or unusual headaches
  • eye sensitivity to light
  • eye problems
  • rapid heartbeat
  • increased sweating
  • extreme tiredness
  • weight gain or weight loss
  • feeling more hungry or thirsty than usual
  • urinating more often than usual
  • hair loss
  • feeling cold
  • constipation
  • your voice gets deeper
  • dizziness or fainting
  • changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

Kidney problems

  • decrease in your amount of urine
  • blood in your urine
  • swelling of your ankles
  • loss of appetite

Skin problems

  • rash
  • itching
  • skin blistering or peeling
  • painful sores or ulcers in your mouth or your nose, throat, or genital area
  • fever or flu-like symptoms
  • swollen lymph nodes

Problems can also happen in other organs.
These are not all of the signs and symptoms of immune system problems that can happen with TECENTRIQ or TECENTRIQ HYBREZA. Call or see your healthcare provider right away for any new or worsening signs or symptoms, including:

  • Chest pain, irregular heartbeat, shortness of breath, or swelling of ankles
  • Confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs
  • Double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight
  • Persistent or severe muscle pain or weakness, muscle cramps
  • Low red blood cells, bruising

Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include:

  • chills or shaking
  • itching or rash
  • flushing
  • shortness of breath or wheezing
  • dizziness
  • feeling like passing out
  • fever
  • back or neck pain

Rejection of a transplanted organ or tissue. Your healthcare provider should tell you what signs and symptoms you should report and monitor you depending on the type of organ or tissue transplant that you have had.

Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with TECENTRIQ or TECENTRIQ HYBREZA. Your healthcare provider will monitor you for these complications.

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with TECENTRIQ or TECENTRIQ HYBREZA. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with TECENTRIQ or TECENTRIQ HYBREZA if you have severe side effects.

Before you receive TECENTRIQ or TECENTRIQ HYBREZA, tell your healthcare provider about all of your medical conditions, including if you:

  • have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus
  • have received an organ or tissue transplant, including corneal transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. TECENTRIQ and TECENTRIQ HYBREZA can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with TECENTRIQ or TECENTRIQ HYBREZA. Females who are able to become pregnant:
    • Your healthcare provider should do a pregnancy test before you start treatment with TECENTRIQ or TECENTRIQ HYBREZA.
    • You should use an effective method of birth control during your treatment and for at least 5 months after the last dose of TECENTRIQ or TECENTRIQ HYBREZA.
  • are breastfeeding or plan to breastfeed. It is not known if TECENTRIQ or TECENTRIQ HYBREZA passes into your breast milk. Do not breastfeed during treatment and for at least 5 months after the last dose of TECENTRIQ or TECENTRIQ HYBREZA.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of TECENTRIQ when used alone include:

  • feeling tired or weak
  • decreased appetite
  • nausea
  • cough
  • shortness of breath

The most common side effects of TECENTRIQ HYBREZA when used alone include:

  • feeling tired or weak
  • muscle or bone pain
  • cough
  • shortness of breath
  • decreased appetite

The most common side effect of TECENTRIQ and TECENTRIQ HYBREZA when used alone in MIBC is:

  • urinary tract infection

TECENTRIQ and TECENTRIQ HYBREZA may cause fertility problems in females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of TECENTRIQ and TECENTRIQ HYBREZA. Ask your healthcare provider or pharmacist for more information about the benefits and side effects of TECENTRIQ and TECENTRIQ HYBREZA.

You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.

Please see full Prescribing Information for TECENTRIQ and TECENTRIQ HYBREZA and the Medication Guides for TECENTRIQ and TECENTRIQ HYBREZA for additional Important Safety Information.

 

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