Possible side effects and how to manage them

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Safety information to be aware of

There are potential side effects that can occur with treatment. If you experience any symptoms while taking your medicines, it’s a good idea to take note of them and discuss them with your doctor.

Possible serious side effects with TECENTRIQ include, but are not limited to:

  • lung problems
  • intestinal problems
  • liver problems
  • hormone gland problems
  • kidney problems
  • skin problems
  • problems in other organs
  • severe infusion reactions
  • complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic)

The most common side effects of TECENTRIQ when used in lung cancer with other anti-cancer medicines include:

  • feeling tired or weak
  • nausea
  • hair loss
  • constipation
  • diarrhea
  • decreased appetite

Managing certain side effects with TECENTRIQ

Managing certain side effects with TECENTRIQ® (atezolizumab)

These suggestions may help you with overall wellness as well as manage any side effects you may experience while taking TECENTRIQ. Implementing healthy habits may help you feel more balanced and comfortable during treatment. This advice is not meant to replace the advice of your healthcare provider.

4 healthy habits

Building a healthy routine during treatment is important. See if you can add these 4 tips into your daily routine.

Water bottle tilted at a right diagonal with one droplet coming out

Drink plenty of liquids, whether it’s water, soup, milk, or even smoothies

Figure walking

Try stretching or taking short walks throughout the day

Bowl with three pieces of salad floating above

Eat foods full of nutrients, proteins and carbs to provide energy and help keep up your strength

Crescent moon with three z's on top of it

Aim to get 7-8 hours of quality sleep each night by keeping your bedroom cool and avoiding screen time

Tips to manage common side effects

As you get started, it’s helpful to know what to expect from treatment, including that TECENTRIQ may cause side effects. If you experience side effects, talk with your healthcare team. Here are some things you can try that may help:

Circle with figure stretching inside
Tired or weak?

Try the following to improve energy:

  • Balance activity and rest; short naps and short walks both have benefits
  • Consider a change in diet; some foods may boost energy
  • Talk with your doctor if you are having trouble sleeping at night
  • Incorporate activities you enjoy into your daily routine
Circle with a spoon and fork placed vertically next to each other inside
Not much of an appetite?

Consider these nutrition tips:

  • Eat 5 to 6 small meals a day, snack when you're hungry, and drink fluids between meals 
  • Switch it up: you may find that certain foods and mealtimes work better than others 
  • Keep high-protein, high-calorie snacks handy like dried fruits, yogurt, cheese, and eggs 
 Circle with figure sitting cross legged with arms extending straight out to either side
Feeling nauseous or vomiting?

These ideas may offer relief:

  • Distract yourself by doing relaxing activities like listening to music 
  • Eat smaller meals more often 
  • Stay hydrated
 Circle with one head of broccoli inside

Try the following suggestions:

  • Incorporate foods high in fiber into your diet such as beans, berries, broccoli, oatmeal, and whole wheat bread and pasta 
  • Drink more liquids such as water, juice, or tea 
  • Ask your doctor about using a laxative or stool softener
Experiencing diarrhea?

These tips may help you feel more comfortable:

  • Choose foods that are easy to digest like bananas, rice, applesauce, and toast 
  • Avoid caffeine, alcohol, dairy, fat, orange juice, prune juice, and spicy foods 
  • Drink water or other hydrating beverages 

Remember that these tips should be reviewed with your healthcare team before adding them into your everyday routine. Your healthcare team is there to support you. We encourage you to be familiar with all potential side effects and to call your doctor if you experience difficulty while taking TECENTRIQ.

Important Safety Information and Indication



TECENTRIQ is a prescription medicine used to treat adults with:

A type of lung cancer called small cell lung cancer (SCLC). TECENTRIQ may be used with the chemotherapy medicines carboplatin and etoposide as your first treatment when your lung cancer:

  • is a type called “extensive-stage small cell lung cancer,” which means that it has spread or grown.

It is not known if TECENTRIQ is safe and effective in children.

What is the most important information about TECENTRIQ?
TECENTRIQ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended.

Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including:

Lung problems

  • cough
  • shortness of breath
  • chest pain

Intestinal problems

  • diarrhea (loose stools) or more frequent bowel movements than usual
  • stools that are black, tarry, sticky, or have blood or mucus
  • severe stomach-area (abdomen) pain or tenderness

Liver problems

  • yellowing of your skin or the whites of your eyes
  • severe nausea or vomiting
  • pain on the right side of your stomach area (abdomen)
  • dark urine (tea colored)
  • bleeding or bruising more easily than normal

Hormone gland problems

  • headaches that will not go away or unusual headaches 
  • eye sensitivity to light 
  • eye problems 
  • rapid heartbeat 
  • increased sweating 
  • extreme tiredness 
  • weight gain or weight loss 
  • feeling more hungry or thirsty than usual
  • urinating more often than usual 
  • hair loss 
  • feeling cold 
  • constipation 
  • your voice gets deeper 
  • dizziness or fainting 
  • changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

Kidney problems

  • decrease in your amount of urine 
  • blood in your urine
  • swelling of your ankles 
  • loss of appetite

Skin problems

  • rash 
  • itching 
  • skin blistering or peeling
  • painful sores or ulcers in mouth or nose, throat, or genital area 
  • fever or flu-like symptoms 
  • swollen lymph nodes

Problems can also happen in other organs.
These are not all of the signs and symptoms of immune system problems that can happen with TECENTRIQ. Call or see your healthcare provider right away for any new or worse signs or symptoms, including:

  • Chest pain, irregular heartbeat, shortness of breath, or swelling of ankles
  • Confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs
  • Double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight
  • Persistent or severe muscle pain or weakness, muscle cramps
  • Low red blood cells, bruising

Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include:

  • chills or shaking 
  • itching or rash 
  • flushing 
  • shortness of breath or wheezing
  • dizziness 
  • feeling like passing out 
  • fever 
  • back or neck pain

Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with TECENTRIQ. Your healthcare provider will monitor you for these complications.

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with TECENTRIQ. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with TECENTRIQ if you have severe side effects.

Before you receive TECENTRIQ, tell your healthcare provider about all of your medical conditions, including if you:

  • have immune system problems such as Crohn’s disease, ulcerative colitis, or lupus
  • have received an organ transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. TECENTRIQ can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with TECENTRIQ. Females who are able to become pregnant:
    • Your healthcare provider should do a pregnancy test before you start treatment with TECENTRIQ.
    • You should use an effective method of birth control during your treatment and for at least 5 months after the last dose of TECENTRIQ.
  • are breastfeeding or plan to breastfeed. It is not known if TECENTRIQ passes into your breast milk. Do not breastfeed during treatment and for at least 5 months after the last dose of TECENTRIQ.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of TECENTRIQ when used in lung cancer with other anti-cancer medicines include:

  • feeling tired or weak
  • nausea
  • hair loss
  • constipation
  • diarrhea
  • decreased appetite

TECENTRIQ may cause fertility problems in females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of TECENTRIQ. Ask your healthcare provider or pharmacist for more information about the benefits and side effects of TECENTRIQ.

You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
You may also report side effects to Genentech at 1-888-835-2555.

Please see full Prescribing Information and Medication Guide for additional Important Safety Information.