When it’s diagnosed, melanoma is assigned a stage. The stage is based on how far the cancer has spread and ranges from 0 to IV. When the cancer reaches stage IV, it has spread to other parts of the body and is considered metastatic or advanced melanoma. Your healthcare provider will determine the stage of your cancer. Knowing this information can help you and your doctor choose the most appropriate treatment option.
The stages of melanoma:
Stage 0: Abnormal cell changes occur in the top layer of the skin. These cell changes are found in the melanocytes. This stage is also referred to as melanoma in situ.
Stage I: The melanoma has grown, but not spread beyond the epidermis, the top layer of the skin.
Stage II: At this stage, the melanoma has spread down close to the subcutaneous tissue.
Stage III: It has now spread locally, particularly to the nearby lymph nodes. Some stage III melanomas may not be able to be removed by surgery.
Stage IV: Also called metastatic melanoma or advanced melanoma. The melanoma has spread to other organs in the body, most often the lungs, liver, brain, bone, or gastrointestinal tract. It may also spread to distant areas of the skin or distant lymph nodes.
What is TECENTRIQ?
TECENTRIQ is a prescription medicine used to treat adults with:
A type of skin cancer called melanoma. TECENTRIQ may be used with the medicines cobimetinib and vemurafenib when your melanoma:
It is not known if TECENTRIQ is safe and effective in children.
What is the most important information about TECENTRIQ?
TECENTRIQ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended.
Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including:
Hormone gland problems
Problems can also happen in other organs.
These are not all of the signs and symptoms of immune system problems that can happen with TECENTRIQ. Call or see your healthcare provider right away for any new or worse signs or symptoms, including:
Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include:
Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with TECENTRIQ. Your healthcare provider will monitor you for these complications.
Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with TECENTRIQ. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with TECENTRIQ if you have severe side effects.
Before you receive TECENTRIQ, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
The most common side effects of TECENTRIQ when used in melanoma with cobimetinib and vemurafenib include:
TECENTRIQ may cause fertility problems in females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility.
These are not all the possible side effects of TECENTRIQ. Ask your healthcare provider or pharmacist for more information about the benefits and side effects of TECENTRIQ.
You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.
Please see full Prescribing Information and Medication Guide for additional Important Safety Information.
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