Hearing your doctor say you have advanced melanoma can bring up a lot of emotions. It can be helpful to have a better understanding of what melanoma is.
Melanoma is a kind of skin cancer. It starts when the cells that give the skin its tan or brown color, called melanocytes, grow out of control and form tumors. Melanoma tumors are often brown or black, but can also be pink, tan, or sometimes even white. These tumors often first appear on the chest and back in men, and on the legs for women. However, they can appear anywhere on the body, either raised or flat, depending on how they develop.
As the disease progresses, it can spread to other parts of the body, particularly if it’s not detected and treated early. This process is called “metastasis.”
In healthy cells, the BRAF protein helps to regulate normal cell growth. In some melanoma cells, a specific error, or mutation, occurs in the BRAF gene (known as BRAF V600). This may lead to abnormal growth and causes cells to duplicate. This abnormal growth of melanoma cells can cause the melanoma to spread to other parts of the skin or body.
It’s important to have your healthcare provider check to see if your tumor contains a BRAF V600 mutation, so that together you can develop the best plan for your treatment.
What is TECENTRIQ?
TECENTRIQ is a prescription medicine used to treat adults with:
A type of skin cancer called melanoma. TECENTRIQ may be used with the medicines cobimetinib and vemurafenib when your melanoma:
It is not known if TECENTRIQ is safe and effective in children.
What is the most important information about TECENTRIQ?
TECENTRIQ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended.
Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including:
Hormone gland problems
Problems can also happen in other organs.
These are not all of the signs and symptoms of immune system problems that can happen with TECENTRIQ. Call or see your healthcare provider right away for any new or worse signs or symptoms, including:
Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include:
Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with TECENTRIQ. Your healthcare provider will monitor you for these complications.
Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with TECENTRIQ. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with TECENTRIQ if you have severe side effects.
Before you receive TECENTRIQ, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
The most common side effects of TECENTRIQ when used in melanoma with cobimetinib and vemurafenib include:
TECENTRIQ may cause fertility problems in females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility.
These are not all the possible side effects of TECENTRIQ. Ask your healthcare provider or pharmacist for more information about the benefits and side effects of TECENTRIQ.
You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.
Please see full Prescribing Information and Medication Guide for additional Important Safety Information.
The information contained in this section of the site is intended for U.S. healthcare professionals only. Click "OK" if you are a healthcare professional.
The link you have selected will take you away from this site to one that is not owned or controlled by Genentech, Inc. Genentech, Inc. makes no representation as to the accuracy of the information contained on sites we do not own or control. Genentech does not recommend and does not endorse the content on any third-party websites. Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites.