Your treatment will consist of TECENTRIQ, along with 2 other medicines: COTELLIC® (cobimetinib) and ZELBORAF® (vemurafenib)
These 3 medicines together treat a type of skin cancer called BRAF V600+ advanced melanoma.
Your healthcare provider will give TECENTRIQ into your vein through an intravenous (IV) line. The first TECENTRIQ infusion is given over 60 minutes. If tolerated, the following infusions of TECENTRIQ may be given over 30 minutes.
COTELLIC and ZELBORAF are taken orally. Take them exactly as your healthcare provider tells you to.
Things to remember:
This treatment combination is taken in cycles. Each cycle lasts 28 days, which equals 4 weeks. Cycle 1 will be different from all the following cycles, including Cycle 2 and beyond.
Your healthcare provider will decide how long you may be on treatment. If at any point the disease progresses or the treatments cannot be tolerated, treatment may be stopped. If you experience any side effects, talk to your healthcare provider, as dosing may be modified.
*TECENTRIQ will be given as 840 mg every 2 weeks, 1200 mg every 3 weeks, or 1680 mg every 4 weeks.
For COTELLIC, if you miss a dose or vomit after taking your dose, take the next dose as scheduled.
For ZELBORAF, do not take an additional dose if you vomit after taking your scheduled dose. Take your next dose at the regular time. If you miss a dose, take it as soon as you remember. If it is within 4 hours of your next scheduled dose, just take the next dose at the regular time. Do not make up for the missed dose.
It’s important to follow the instructions from your healthcare provider on how and when to take your treatment. This downloadable schedule can help you stay on top of your treatment.
What is TECENTRIQ?
TECENTRIQ is a prescription medicine used to treat adults with:
A type of skin cancer called melanoma. TECENTRIQ may be used with the medicines cobimetinib and vemurafenib when your melanoma:
It is not known if TECENTRIQ is safe and effective in children.
What is the most important information about TECENTRIQ?
TECENTRIQ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended.
Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including:
Hormone gland problems
Problems can also happen in other organs.
These are not all of the signs and symptoms of immune system problems that can happen with TECENTRIQ. Call or see your healthcare provider right away for any new or worse signs or symptoms, including:
Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include:
Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with TECENTRIQ. Your healthcare provider will monitor you for these complications.
Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with TECENTRIQ. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with TECENTRIQ if you have severe side effects.
Before you receive TECENTRIQ, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
The most common side effects of TECENTRIQ when used in melanoma with cobimetinib and vemurafenib include:
TECENTRIQ may cause fertility problems in females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility.
These are not all the possible side effects of TECENTRIQ. Ask your healthcare provider or pharmacist for more information about the benefits and side effects of TECENTRIQ.
You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.
Please see full Prescribing Information and Medication Guide for additional Important Safety Information.
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