a protein made by the immune system during an immune response. Antibodies attach to specific cells and can affect the immune system’s ability to target and kill cells.
a specific mutation (change) in the BRAF gene. It can lead to abnormal cell growth, which contributes to the growth of cancer cells.
this gene makes a protein called BRAF, which is involved in sending signals in cells to promote rapid cell growth.
a biological molecule that is found in blood, other body fluids, or body tissues. It may be a sign of a normal or abnormal process, or of a condition or disease. Also called molecular marker or signature molecule.
a piece of DNA inside each cell. Most genes contain the information for making a specific protein. For example, the BRAF gene makes the BRAF protein.
a collection of organs, special cells, and substances that help protect you from infections and diseases.
a treatment using substances that stimulate or suppress the immune system to help the body fight cancer, infection, and disease. Some types of immunotherapy only target certain cells of the immune system. Others affect the immune system in a general way. Immunotherapy may also affect normal cells.
this term applies to abnormal cells that are found only in the place where they first formed in the body. These abnormal cells may become cancer and spread to nearby normal tissue.
a method of putting fluids, including medicine, into the bloodstream. Also called intravenous (IV) infusion.
any sign or symptom you might experience during or soon after the infusion of fluids, including medicine/s, into the bloodstream.
a small bean-shaped structure that is part of the body’s immune system. Lymph nodes filter substances that travel through the lymphatic fluid and contain white blood cells (lymphocytes) that help the body fight infection and disease.
the middle value, or number, in a set of measurements that have been put in order from lowest to highest.
cells that produce a pigment called melanin, which gives skin its color.
a type of skin cancer that develops when the cells that give the skin its color (melanocytes) start to grow out of control. It may begin in a mole (skin melanoma), but can also begin in other pigmented tissues, such as in the eye or in the intestines.
the spread of cancer from where it originated to other places in the body.
a change in the DNA of a cell. Mutations may be caused by mistakes during cell division or caused by substances in the environment that damage the DNA. Mutations can be harmful, helpful, or have no effect.
a protein found on the surface of many cells, including cancer cells. This protein can affect the immune system’s ability to target and attack cells.
a molecule that is the building block of the cells in the body; needed for the body to function properly.
unable to be removed with surgery.
What is TECENTRIQ?
TECENTRIQ is a prescription medicine used to treat adults with:
A type of skin cancer called melanoma. TECENTRIQ may be used with the medicines cobimetinib and vemurafenib when your melanoma:
It is not known if TECENTRIQ is safe and effective in children.
What is the most important information about TECENTRIQ?
TECENTRIQ can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended.
Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including:
Hormone gland problems
Problems can also happen in other organs.
These are not all of the signs and symptoms of immune system problems that can happen with TECENTRIQ. Call or see your healthcare provider right away for any new or worse signs or symptoms, including:
Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include:
Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with TECENTRIQ. Your healthcare provider will monitor you for these complications.
Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with TECENTRIQ. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with TECENTRIQ if you have severe side effects.
Before you receive TECENTRIQ, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
The most common side effects of TECENTRIQ when used in melanoma with cobimetinib and vemurafenib include:
TECENTRIQ may cause fertility problems in females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility.
These are not all the possible side effects of TECENTRIQ. Ask your healthcare provider or pharmacist for more information about the benefits and side effects of TECENTRIQ.
You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.
Please see full Prescribing Information and Medication Guide for additional Important Safety Information.
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