Safety information to be aware of

As with any medicine, there are potential side effects that can occur with treatment. If you experience any symptoms while taking your medicines, it’s a good idea to take note of them and discuss them at your next appointment. You can use this downloadable side effect tracker to record any symptoms you experience.


Possible serious side effects with TECENTRIQ include, but are not limited to:

  • lung problems
  • intestinal problems
  • liver problems
  • hormone gland problems
  • kidney problems
  • skin problems
  • problems in other organs
  • severe infusion reactions
  • complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic)


The most common side effects of TECENTRIQ when used in melanoma with cobimetinib and vemurafenib include:

  • skin rash
  • joint, muscle, or bone pain
  • feeling tired or weak
  • liver injury
  • fever
  • nausea
  • itching
  • swelling of legs or arms
  • mouth swelling (sometimes with sores)
  • low thyroid hormone levels
  • sunburn or sun sensitivity

Managing certain side effects

If you experience side effects, always talk to your healthcare provider first. There are some things you can try on your own that may also help:

Low energy? If you’re feeling tired, try to take short naps.

Experiencing diarrhea? Make sure to stay hydrated. You can also try eating 5-6 small meals a day.

Not much of an appetite? Try keeping track of your meals so you know which mealtimes and foods work best for you. Also, physical activities can help give you more of an appetite. Check with your doctor before starting any type of new exercise regimen.