Your treatment will consist of TECENTRIQ, along with 2 other medicines: COTELLIC® (cobimetinib) and ZELBORAF® (vemurafenib)

These 3 medicines together treat a type of skin cancer called BRAF V600+ advanced melanoma.

How is treatment given?


Your healthcare provider will give TECENTRIQ into your vein through an intravenous (IV) line. The first TECENTRIQ infusion is given over 60 minutes. If tolerated, the following infusions of TECENTRIQ may be given over 30 minutes.


COTELLIC and ZELBORAF are taken orally. Take them exactly as your healthcare provider tells you to.

Things to remember:

  • Do not change your dose or stop taking unless your healthcare provider tells you to
  • Take doses with or without food
  • Store both medications at room temperature
  • Store in original container with lid tightly closed (for ZELBORAF only)
  • Do not crush or chew tablets (for ZELBORAF only)

How often are the medicines taken?

This treatment combination is taken in cycles. Each cycle lasts 28 days, which equals 4 weeks. Cycle 1 will be different from all the following cycles, including Cycle 2 and beyond.

This dosing table shows which medicines to take during each cycle, how much of each medicine to take, and how often to take them

Your healthcare provider will decide how long you may be on treatment. If at any point the disease progresses or the treatments cannot be tolerated, treatment may be stopped. If you experience any side effects, talk to your healthcare provider, as dosing may be modified.

Miss a dose of your oral medicines? Here’s what to do:

For COTELLIC, if you miss a dose or vomit after taking your dose, take the next dose as scheduled.

For ZELBORAF, do not take an additional dose if you vomit after taking your scheduled dose. Take your next dose at the regular time. If you miss a dose, take it as soon as you remember. If it is within 4 hours of your next scheduled dose, just take the next dose at the regular time. Do not make up for the missed dose.


It’s important to follow the instructions from your healthcare provider on how and when to take your treatment. This downloadable schedule can help you stay on top of your treatment.

Preparing for treatment and staying on track

For your infusions

  • Stay warm
    Some people feel cold during their infusion, so you may want to bring a warm blanket

  • Bring a companion
    Ask a family member or friend to give you a ride and keep you company during your infusion

  • Dress comfortably
    Some appointments take longer than others, so you may want to wear comfortable clothes

  • Pass the time
    Entertain yourself with a book, a tablet, or your phone loaded with a TV show or podcast

  • Pack a snack
    Ask your care team if it’s okay to bring some light snacks or a bottle of water

  • Take notes
    Bring a pen and your treatment journal (or a notepad) to jot down any questions or thoughts that come up

For your oral medicines

  • Get organized 
    Keep your prescription bottles in a place where you will remember to take your medicines

  • Use a treatment journal or calendar
    Calendars or notebooks are visual tools that can help you keep track of your treatment schedule, including the week you do not take COTELLIC. If you think this might be helpful, you can download the dosing guide to stay on track

  • Keep at least one visual reminder somewhere in your house
    A note on the refrigerator, a bulletin board, or a place you go to every day in your house may ensure that you take your medicine before leaving home

  • Set up a routine
    Taking your pills at the same time every day, such as in the morning or with a meal, can make it easier to remember

  • Use alarms or reminder calls
    Setting up an alarm on your phone or computer can be helpful. You may even consider having a loved one call you to help you remember